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dc.contributor.authorDaglia, Maria
dc.contributor.authorDi Lorenzo, Arianna
dc.contributor.authorNabavi, Seyed F.
dc.contributor.authorTalas, Zeliha S.
dc.contributor.authorNabavi, Seyed M.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2014
dc.identifier.issn1389-2010
dc.identifier.issn1873-4316
dc.identifier.urihttps://dx.doi.org/10.2174/138920101504140825120737
dc.identifier.urihttps://hdl.handle.net/11480/4241
dc.descriptionWOS: 000340715400008en_US
dc.descriptionPubMed ID: 24938889en_US
dc.description.abstractGallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part of more complex molecules, such as ester derivatives or polymers. In nature, gallic acid and its derivatives are present in nearly every part of the plant, such as bark, wood, leaf, fruit, root and seed. They are present in different concentrations in common foodstuffs such as blueberry, blackberry, strawberry, plums, grapes, mango, cashew nut, hazelnut, walnut, tea, wine and so on. After consumption, about 70% of gallic acid is adsorbed and then excreted in the urine as 4-O-methylgallic acid. Differently, the ester derivatives of gallic acid, such as catechin gallate ester or gallotannins, are hydrolyzed to gallic acid before being metabolized to methylated derivatives. Gallic acid is a well known antioxidant compounds which has neuroprotective actions in different models of neurodegeneration, neurotoxicity and oxidative stress. In this review, we discuss about the neuroprotective actions of gallic acid and derivatives and their potential mechanisms of action.en_US
dc.language.isoengen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGallic aciden_US
dc.subjectneuroprotective activityen_US
dc.subjectpolyphenosen_US
dc.subjectprotective activityen_US
dc.titlePolyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!en_US
dc.typearticleen_US
dc.relation.journalCURRENT PHARMACEUTICAL BIOTECHNOLOGYen_US
dc.departmentNiğde ÖHÜen_US
dc.identifier.volume15en_US
dc.identifier.issue4en_US
dc.identifier.startpage362en_US
dc.identifier.endpage372en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthor[0-Belirlenecek]
dc.identifier.doi10.2174/138920101504140825120737


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