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dc.contributor.authorCelik, Ayla
dc.contributor.authorDiler, Songuel Budak
dc.contributor.authorEke, Dilek
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2010
dc.identifier.issn1044-5498
dc.identifier.urihttps://dx.doi.org/10.1089/dna.2009.0996
dc.identifier.urihttps://hdl.handle.net/11480/4873
dc.descriptionWOS: 000278871500002en_US
dc.descriptionPubMed ID: 20218900en_US
dc.description.abstractThe micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans exposed to occupational and environmental agents. The MN test is used as an indicator of genotoxic exposition, since it is associated with chromosome aberrations. An increased mutation rate in oral squamous cells, which is indicated by an increased MN frequency, is also related to the development of oral mucosa diseases, such as carcinomas. We evaluated MN frequencies and other nuclear changes (NCs), karyorrhexis (KR), karyolysis (KL), broken egg (BE), and binucleus in buccal mucosa cells of 60 painters (30 smokers and 30 nonsmokers) and 60 healthy control subjects (30 smoker and 30 nonsmoker). Microscopic observation of 3000 cells per individual was performed in both painters and control subjects. In the control group and the exposed group, for each person repair index (RI) was calculated via the following formula: (KR+KL)/(BE+MN). The results showed a statistically significant increase in the frequency of MN in buccal epithelial cells of the exposed group compared with the control group (p<0.05). Smokers and nonsmokers differed with respect to the incidence of MN and NCs in all groups. In painters, RI was less than that in the control group. There was a significant difference between painters and the control group (p<0.01) for RI. We believe that determination of RI in addition to NCs and the MN will present a new approach to genotoxicity studies of a population.en_US
dc.language.isoengen_US
dc.publisherMARY ANN LIEBERT INCen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[0-Belirlenecek]en_US
dc.titleAssessment of Genetic Damage in Buccal Epithelium Cells of Painters: Micronucleus, Nuclear Changes, and Repair Indexen_US
dc.typearticleen_US
dc.authorid0000-0002-0127-3639en_US
dc.relation.journalDNA AND CELL BIOLOGYen_US
dc.departmentNiğde ÖHÜen_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.startpage277en_US
dc.identifier.endpage284en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthor[0-Belirlenecek]
dc.identifier.doi10.1089/dna.2009.0996


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